PFIG people

We are an interdisciplinary team of clinicians, neuroscientists, physicists, and bioengineers.

If you are interested in joining us, we have PhD student opportunities available on the: King’s College London MRC doctoral training partnership in biomedical sciences (KCL MRC DTP), EPSRC CDT in Smart Medical Imaging, the MRC-Sackler PhD fellowship scheme through the MRC Centre for Neurodevelopmental Disorders, and the London Interdisciplinary Doctoral Programme (LIDo).

Dr Tomoki Arichi (Group head)

https://kclpure.kcl.ac.uk/portal/tomoki.arichi.html

https://orcid.org/0000-0002-3550-1644

Tom is a MRC Clinician Scientist and Reader in Perinatal Imaging at the Centre for the Developing Brain, King’s College London. He is also group lead in the MRC Centre for Neurodevelopmental Disorders (CNDD). His current work aims to apply non-invasive imaging techniques (EEG, functional MRI and simultaneous EEG-fMRI) to characterise the development of functional activity in the human brain, during fetal and preterm life and following brain injury. He is also aiming to gain a deeper understanding of the underlying biophysics of the fMRI signal in the newborn brain. He also holds a visiting position in the Human Robotics group at Imperial College London, where they are developing novel tools for use in the MRI scanner and automated rehabilitative strategies for young infants who have suffered brain injury.  

Tom also holds an honorary position as a Consultant in Paediatric Neurodisability in the Evelina London Children’s Hospital. His clinical work is focused on the early identification and resulting management of the disabilities associated with perinatal brain injury.

Tom’s publications on Google Scholar

Dr Slava Karolis (Postdoctoral Research Associate)

Slava completed his PhD in the Institute of Cognitive Neuroscience (University College London) where he studied the topic of number representations in the human brain. His first postdoc was in the Institute of Psychiatry (King’s College London) where, as a member of the Neurodevelopment and Mental Health Group, he was working on the characterisation of anatomical and behavioural consequences of very preterm birth from adolescence into adulthood. He then spent several months in France (Institut du Cerveau et de la Moelle épinière, Hôpital de la Salpêtrière, Sorbonne) working on the atlas of brain regions that show functional hemispheric specialisation and characterising their structural connectivity. In 2018 Slava joined the developing Human Connectome Project as a member of the Analysis Group in FMRIB, Oxford, where he undertook studying signal properties of the in-utero functional MRI and developing an analytical pipeline for these data. He now continues this work as a PFIGist in the Centre for Developing Brain. His main research interest is fetal brain fMRI.

Slava’s preprint about maturational functional networks in the fetal brain:

Karolis et al. Maturational networks of fetal brain activity. BioRxiv 2022:
https://doi.org/10.1101/2022.06.14.495883

Sian Wilson (MRC-Sackler CNDD PhD student)

Siân is an MRC-Sackler PhD student at the Centre for Neurodevelopmental Disorders, Kings College London co-supervised with Dr Jonathan O’Muircheartaigh and Professor David Edwards. She obtained a BSc Biochemistry at the University of York in 2018. During her undergraduate studies she spent a year at the Centre for Genomic Regulation, Barcelona in the lab of Prof. Mara Dierssen working on gene-environment interactions in a mouse model of Down’s Syndrome. Siân then completed an MSc Neuroscience at University College London, where she worked with Prof. Michael Hausser, characterising hippocampal neural ensembles using calcium imaging and optogenetics.

Siân joined the Centre for the Developing Brain at King’s College London in 2019, where she began her PhD working on fetal diffusion MRI, characterising the in-utero development of white matter tracts. Siân’s PhD work will aim to better understand how factors in the in utero and ex utero environment can perturb a healthy developing trajectory, which she is investigating by comparing structural brain MRI data of fetuses and neonates in India, the UK and the USA. 

Sian’s publications:

Wilson et al. Development of human white matter pathways in utero over the second and third trimester. PNAS 2021; 118 (20) e2023598118.

Ryan Stanyard (MRC CDT PhD student)

Ryan is an MRC PhD student at the Centre for the Developing Brain and Department of Forensic and Neurodevelopmental Sciences, King’s College London, co-supervised with Dr Dafnis Batalle and Professor Grainne McAlonan. Ryan obtained a BSc in Neuroscience and Psychology from Keele University in 2018, and then completed an MSc in Neuroimaging at King’s College London, where he worked with Professor Robert Leech and Dr James Cole, exploring the potential for near-real time active acquisition and processing of ASL data.

Ryan joined the Centre for the Developing Brain at King’s College London in 2019, completing an MRes in Biotranslational Medicine, where he began his PhD working on exploring computation models of whole brain connectivity using neonatal diffusion and functional MRI. Ryan’s PhD work will aim to better understand how the coupling of structure and function in the brain changes across the lifespan, primarily in neonates of differing degrees of prematurity. This work will leverage biophysical models of emergent brain activity and empirical EEG, diffusion and functional MRI data.J

Jucha Willers Moore (MRC-Sackler CNDD PhD Student)

Jucha is an MRC-Sackler PhD student at the Centre for Neurodevelopmental Disorders, co-supervised with Dr. Laura Andreae and Dr. Katie Long. She obtained a MSci Neuroscience at University College London in 2020, where she worked with Dr. Lorenzo Fabrizi investigating the development of neurovascular coupling in neonates and the development of nociceptive brain states in the preterm infant using EEG. During her undergraduate studies, Jucha was awarded a Wellcome Trust Biomedical Vacation Scholarship in 2019 to investigate the regulation of neurotrophic factor uptake at the neuromuscular junction at the UCL Institute of Neurology wit Prof. Giampietro Schiavo.

Jucha joined the Centre for the Developing Brain at King’s College London in 2021 where she began her PhD working on fetal functional MRI, characterising the development of spontaneous neural activity in utero. Jucha is also working with Dr. Laura Andreae at Centre for Neurodevelopmental Disorders where she is looking at the development of spontaneous activity patterns in the human fetal cortex in vitro using calcium imaging. By combining these two techniques, Jucha’s PhD will aim to understand how spontaneous neural activity changes from within local circuitry to across large-scale networks in the fetus throughout the second and third trimesters of gestation.

Dr Sara Neumane (Bettencourt Foundation fellow)

Sara has a double background and is qualified in France as an MD in Paediatrics (focusing on Neuropaediatrics and rehabilitation) but also has a PhD in Neuroscience (focusing on functional somatotopy, motor system and compensatory mechanisms in a pathological context).

Her research interests include studying structural & functional brain networks in typical and atypical development, sensorimotor system development and post-injury neuroplasticity, and functional outcomes following early acquired brain injuries.

Alumnus: Dr Maria Yanez Lopez (Postdoctoral Research Associate 2019-2021)

Maria’s research interests focus on the development of molecular magnetic resonance imaging (MRI) to investigate the biochemistry of neurological and psychiatric disorders, with a view to characterising disease onset, improving early diagnosis and assessment of therapy effectiveness. Her background includes research in traumatic brain injury and Alzheimer’s Disease, with techniques such as magnetic resonance spectroscopy (MRS) and chemical exchange saturation transfer (CEST), both at clinical fields (3T) and high fields (9.4T preclinical).

Her work with us focused on studying the balance between excitatory (glutamate) and inhibitory (Gamma Amino-Butyric Acid (GABA)) neurotransmitter levels in newborn infants who have a high familial risk of developing neurodevelopmental disorders, using edited 1H MRS methods. An abstract presenting this work was recently recognised by a Magnum Cum Laude award as one of the top 15% of abstracts at the ISMRM annual meeting 2020.

Maria is now the MR Physics lead at Swansea University Hospital NHS Trust.

Maria’s PFIG Publications:

Yanez Lopez et al. Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy. Neuroimage 2021

Song et al. Edited Magnetic Resonance Spectroscopy in the neonatal brain. Neuroradiology 2021

Alumnus: Dr Tanya Poppe (Postdoctoral Research Associate 2018-2021)

Tanya is a Research Associate in the Centre for the Developing Brain, King’s College London. Her research interest is understanding brain development in preterm and term neonates. Tanya gained her PhD in 2019 from the University of Auckland for her work studying the neuroprotective effects of perinatal interventions for preterm birth using MRI in babies and children.

Tanya’s work focused on using simultaneous EEG-fMRI in neonates to study the development of functional activity in the human brain. This work was recognised with a Summa cum Laude award as one of the top 5% of abstracts the ISMRM annual meeting 2019.

Tanya is now working for Ixico as a biomarker scientist.

Tanya’s PFIG publications:

T Poppe et al. Individual focused studies of functional brain development in early human infancy. Current Opinions in Behavioural Sciences 2021; 40: 137-43.

Alumnus: Anna Lukens (Neonatal physiotherapist 2019-2021)

Anna worked with the team as a highly specialist neonatal physiotherapist on the neonatal unit at the Evelina London Children’s Hospital from 2017-2021. During this time she completed her MSc in Advanced Paediatric Physiotherapy at University College London and did a research project investigating the predictive validity of the Lacey Assessment for Preterm Infants which is used on the neonatal unit to identify infants at high risk of neurodevelopmental difficulties. From 2019-2021 she worked specifically on the EPSRC funded MAVEHA project to explore methods for quantification of spontaneous motor behaviour in neonates.

Anna is now leading the neonatal physiotherapy service at King’s College Hospital.

Anna’s publications:

Predictive validity of the Lacey Assessment of Preterm infants for motor outcome at 2 years corrected age. AM Lukens, NR Winfield, CA Xanthidis, T Arichi. Early Human Development (in press)

Alumnus: Dr Sofia Dall’Orso (PhD student 2016-2019)

Sofia completed her PhD at Imperial College London in 2019, and is currently a postdoctoral research associate at Chalmers University Sweden and a visiting researcher at King’s College, London. She obtained her Physics BSc at the University of Bologna and the Neurotechnology MRes at Imperial College London as part of the EPSRC CDT (centre for doctoral training) programme. During her PhD, she combined engineering and imaging techniques with robotic tools to perform task-based fMRI on newborn babies. Her research on brain development focused in particular on the sensory system, comprising investigating somatotopic mapping in the preterm brain and the study of associate learning between different sensory modalities. This aimed to better understand how the somatosensory system develops and how it can be influenced by environmental exposure and early sensory experiences.

Sofia is now working for i3tex on product research and development.

Sofia’s PFIG publications:

Dall’Orso et al. Somatotopic mapping of the developing sensorimotor cortex in the preterm human brain. Cerebral Cortex 2018; 28(7): 2507-15.

Dall’Orso et al. Cortical Processing of multimodal sensory learning in human neonates. Cerebral Cortex 2021; 31(3): 1827-36.

Dall’Orso et al. Development of functional organization within the sensorimotor network across the perinatal period. Human Brain Mapping 2022.

Alumnus: Dr Judit Ciarrusta (PhD student 2015-2019)

Judit gained her PhD with us at King’s College London in 2019 as part of Brainview, a Marie Curie Early Career Initiative investigating early autism risk markers. The focus of her PhD was on typical and atypical functional activity development using fMRI data from subjects with family history of autism (high risk) and without family history of psychiatric (low risk) to discern typical from atypical maturation mechanisms. The final goal was to understand the characteristics of typical brain development in order to discern MRI markers that can enable early identification of atypical development before behavioural symptoms emerge.

Judit now has a research fellowship from the Spanish Government to continue her exciting work into early brain development at Pompeu Fabra University, Barcelona.

Judit’s PFIG publications:

Ciarrusta et al. Social brain functional maturation in newborn infants with and without family history of autism spectrum disorder.
JAMA Netw Open. 2019;2(4):e191868.

Ciarrusta et al. Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders.Translational Psychiatry 2020; 10: Article number: 131.

Collaborators:

Our work would not be possible without working closely with colleagues across different fields and in different institutions:

  • Dr Lorenzo Fabrizi (Neuroscience, Physiology & Pharmacology, UCL)
  • Professor Etienne Burdet (Human Robotics Group, Imperial College London)
  • Dr Bernhard Kainz (Computer Science, Imperial College London)
  • Professor Grainne McAlonan (IOPPN, King’s College London)
  • Professor Bill Fifer (Medical Psychology, Columbia University)
  • Dr Jonathan O’Muicheartaigh (King’s College London)
  • Dr Dafnis Batalle (King’s College London)